Dr. Yayoko Ito
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Graduated from Hiroshima University School of Medicine. After working in the Department of General Medicine, he studied under doctors at the forefront of cosmetic medicine. After acquiring knowledge and skills in aesthetics, he became the director of YAYOI CLINIC in 2023. Her specialties include Botox, hyaluronic acid injections, and customized sagging treatment. His motto is to provide natural and pain-free treatments with careful consultation.
What happens if you keep injecting hyaluronic acid? Hyaluronic acid injections are one of the most common cosmetic medical procedures chosen by people who have begun to notice wrinkles. However, some of you may have heard that hyaluronic acid injections can cause lines to darken if you keep injecting hyaluronic acid preparations, or you may have seen images of failed hyaluronic acid injections that were injected too often. In this issue, we introduce the correct knowledge of hyaluronic acid injections and the precautions to be taken when continuing the procedure. Please refer to this information if you are considering the procedure.
Basic Knowledge of Hyaluronic Acid Injection

Before we talk about what happens if you keep injecting hyaluronic acid, let's check what kind of procedure hyaluronic acid injections are in the first place.
■What is Hyaluronic Acid: Its Role in Cosmetic Medicine
Hyaluronic acid is a substance that occurs naturally in the human body, including skin, muscle, cartilage, and brain. One of the major characteristics of hyaluronic acid is its high water-holding capacity, as each gram of hyaluronic acid can hold approximately 6 liters of water,Effects on skin elasticity and moistureThere is a However, the hyaluronic acid content in the body decreases with age. This causes the skin to lose its elasticity and wrinkles and sagging become more noticeable.
Hyaluronic acid preparations work to improve wrinkles and increase the moisture content of the skin. Hyaluronic acid is said to be less likely to cause allergic reactions because it is made from an ingredient that exists naturally in the body. Another advantage is that the treatment time is short and the effect is immediate. Although it varies from person to person, there is almost no downtime, making it an easy choice for busy people.
■Effects and changes due to hyaluronic acid injections
The effects of hyaluronic acid injections begin to appear immediately after the procedure, and gradually blend in as it reacts with the body's own moisture content, taking several weeks to a month to achieve a natural shape. The injected area becomes plump,Skin elasticity and firmness increase, resulting in a more youthful appearanceThe duration of the treatment is generally six months to two years. Generally, hyaluronic acid products last from six months to two years, and the body's mechanisms of metabolism and absorption gradually diminish the power of the hyaluronic acid product.
However, this is not the only effect of hyaluronic acid injections. Because hyaluronic acid injections promote collagen production, long-term effects such as firmness of the skin and improvement of wrinkles and sagging skin can be expected even after the hyaluronic acid preparation has been absorbed.
■Differences in effects and changes according to age and skin type
The effects of hyaluronic acid injections vary with age and skin type. In general,The younger the age, the higher the amount of hyaluronic acid in the body.The skin's elasticity and firmness are relatively preserved. Therefore, natural-looking results can be expected even with a small amount. On the other hand, older patients may require a larger amount of injections due to bone loss and loosening of the ligaments that support the skin.
Also, when hyaluronic acid is injected into dry skin,Expected to increase moisture by moisture retention effectThis can be done. However, since dryness speeds up the breakdown of hyaluronic acid, it is important to carefully moisturize the skin after the procedure. The treated skin should be treated with moisturizing creams and serums to prolong the effects of the hyaluronic acid preparation as much as possible.
Injection site and expected effect
Hyaluronic acid injections are an effective procedure for various areas of the face.
Injection site and effect of hyaluronic acid products
| part | effect |
| 頬 | Facelining
Can also be expected to have a lifting effect. |
| laugh lines | Reduces the appearance of wrinkles and gives a more youthful appearance |
| periorbital puffiness | Eliminate hollows under the eyes
Makes the eyes appear larger and prettier. |
| Forehead and between the eyebrows | Can reduce the appearance of wrinkles and soften the impression of the face.
It also makes you look more youthful. |
| 唇 | Can be thicker, more feminine. |
| 顎 | If the chin is round, inject at the tip of the chin to give it a sharp shape
If the chin is split, it can be injected into the cleft of the chin to create a clean line. |
| 鼻 | Sharpens the line of the nose and creates a small face effect.
It can also make your nose look taller. |
Hyaluronic acid injections also improve the skin's moisture retention and elasticity, which may be expected to result in beautiful skin.
Mechanism of Absorption and Duration of Hyaluronic Acid Preparation
How long do the effects of hyaluronic acid preparations last?Six months to two yearsThis is because hyaluronic acid is degraded and absorbed by the enzyme hyaluronidase. This is because hyaluronic acid is broken down and absorbed by the enzyme hyaluronidase, and the effect wears off. Although the way in which it is broken down and absorbed varies according to lifestyle and body type, the secretion of hyaluronidase does not mean that the treatment effect is permanent.
As the hyaluronic acid preparation is absorbed, the skin gradually returns to its pre-hyaluronic acid injection state. In order to maintain the reduced appearance of wrinkles and sagging skin, it is advisable to inject hyaluronic acid on a regular basis.
What happens if I keep getting hyaluronic acid injections?

Some people may want to improve wrinkles and sagging skin with hyaluronic acid injections, but may feel uneasy if they keep injecting it. However, hyaluronic acid is a component that exists in the human body, so it does not have a significant effect on the body. Also, as mentioned above, it is broken down by enzymes,Low risk because little or no residue in the bodyIt is considered to be a good idea. However, there are risks associated with over-dosing, such as injecting the wrong amount or too short an interval between treatments. When undergoing ongoing treatment, be aware of the risks and have the procedure performed by a doctor you can trust.
Risks of ongoing hyaluronic acid injections
Possible risks associated with continued hyaluronic acid injections include the following
■Unnnnatural finish.
Continuing to apply hyaluronic acid until it is "better to stop" can cause unnatural fullness, hardening, and asymmetry. Also,There is a risk of restricting the movement of facial muscles.It will be. Injections in the proper amount and at the proper intervals are important to achieve a natural-looking result.
■ Increased risk of allergies and side effects
It is important to consider the possibility of allergies and side effects when continuing hyaluronic acid injections. Although there is little downtime, some patients may experience swelling, redness, and itching after the procedure. These are often temporary, but serious risks such as blood flow obstruction due to compression of blood vessels or blindness due to vascular embolization cannot be completely ruled out. As the risk increases with the amount injected, it is important to inject the appropriate amount and to have the procedure performed by a trusted physician.
■You want to deviate from the aesthetic sense and inject more than the necessary amount
If you continue to inject hyaluronic acid, you will become accustomed to having hyaluronic acid preparations injected, and this will spur your desire to inject "more ____". As a result, they may want to inject more than the appropriate amount. In some cases, the desire for extreme changes is more pronounced than the desire for natural-looking results. Hyaluronic acid injections are not about quantity,Appropriate dosage should be applied for a suitable period of time.in mind, and listen carefully to your doctor's advice.
What happens if I stop hyaluronic acid injections?
When hyaluronic acid injections are discontinued, the effect is gradually lost. On the other hand, the effects of hyaluronic acid preparations last from six months to two years, so rapid skin deterioration is unlikely to occur. However, if the plumpness that was achieved by hyaluronic acid injections is lost, the patient may feel that it is not enough. In addition, those whose skin has been aging while receiving hyaluronic acid injections may feel older than before the start of the procedure.
No special care is required when stopping hyaluronic acid injections, but it is important to review skin care and consider other treatments to alleviate some of these discomforts. In addition to hyaluronic acid, there are other treatments that can improve wrinkles and sagging skin, so it is a good idea to consult with a beauty clinic.
■ Conclusion.
Hyaluronic acid injections are an effective treatment for conditions such as wrinkles, sagging, and lack of firmness, and there is generally no problem with continued treatment. However, if an incorrect amount of hyaluronic acid product is continually injected, facial imbalance can occur. The key to preventing disadvantages is to choose a reliable cosmetic clinic. Why not start with a consultation at a clinic with a proven track record?
Aesthetic Dermatology, Aesthetic Medicine, Aesthetic Surgery, Art Make-up Yayoi Clinic (YAYOI CLINIC) in Hiroshima introduces treatments for different problems of the skin, body, and face.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
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Description of treatment] Hyaluronic acid injection
Duration and number of times of treatment] Every 1 time
Cost】 ¥79,800 per unit (+ ¥22,000 application fee) *The number of units used varies depending on the individual.
Risks, side effects, etc.] Allergic reaction, pain, infection, misalignment of correction position, etc.
[Regarding treatment using unapproved medical devices, unapproved pharmaceuticals, etc.
This treatment includes drugs that are not approved in Japan and treatments that differ from their approved use.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
Information on safety, etc. in other countries
-Juviderm Vista® series: approved in Japan for "correction of moderate to severe wrinkles and furrows on the face
There is a possibility that serious risks, side effects, etc. have not been identified.
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief Program.