Dr. Yayoko Ito
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Graduated from Hiroshima University School of Medicine. After working in the Department of General Medicine, he studied under doctors at the forefront of cosmetic medicine. After acquiring knowledge and skills in aesthetics, he became the director of YAYOI CLINIC in 2023. Her specialties include Botox, hyaluronic acid injections, and customized sagging treatment. His motto is to provide natural and pain-free treatments with careful consultation.
If you’re considering Rejuran Eye (polynucleotide) in Hiroshima, you may be concerned about “fine lines around the eyes, dark circles, or dullness caused by dryness,” or perhaps you’d like to “restore firmness to the eye area.” Rejuran Eye is a skin-rejuvenating injection designed to address these specific concerns around the eyes. In this article, YAYOI CLINIC in Hiroshima explains the basics of Rejuran Eye and offers tips on how to choose a clinic. If you’re looking to start age-appropriate eye care, please use this as a guide.
Frequently Asked Questions About Rejuran Eye
Yayoi Clinic answers frequently asked questions about undergoing Rejuran Eye treatment in Hiroshima.
How painful is the treatment?
The pain experienced during a Rejuran Eye treatment mainly consists ofThe sharp pain felt when the needle is inserted and the pain caused by the pressure as the medication is injected into the skinThere are two types. Rejuran Eye has the lowest viscosity among Rejuran products, and because it uses ultra-fine needles, it can be injected relatively smoothly. On the other hand, because the eye area is so delicate, results may vary from person to person, butProne to feeling a prickling sensationThat's the trend.
At Yayoi Clinic, we offer Rejuran injections developed by doctors at BIANCA CLINIC in Tokyo, which are designed to minimize pain through the use of fine needles and specific injection techniques. If necessary, we can also use anesthetic patches or local anesthesia (anesthesia fees apply separately). If you’re concerned about pain, please feel free to consult with us here in Hiroshima.
When can I start wearing makeup?
Resuming my makeup routine is,You can do so the next day or about 24 hours after the treatment.That's correct. However, since the extent of bruising and swelling varies from person to person, it's safest to consult a doctor if you're unsure. To avoid irritating the treated area, limit coverage to using a gentle concealer or similar product, and be careful not to apply strong friction.
At what age would you recommend starting?
There is no specific age restriction for Rejuran Eye.For early anti-aging care* starting in your late 20s, or for more intensive care of fine lines around the eyes and loss of firmness in your 30s through 50s and beyondAs such, it’s a popular choice among people of all ages. If you notice changes such as “dryness around the eyes” or “eye cream alone isn’t enough,” that’s a good time to start using it.
*Age-appropriate skincare
Basics of Rejuran Eye and How to Apply It to the Eye Area
In this section, we’ll explain the basics of Rejuran Eye and how to apply it to the eye area.
What is Rejuran Eye? Its main ingredient is “polynucleotide,” which helps improve skin condition.
Rejuran Eye is a skin-rejuvenating injection whose main ingredient is “polynucleotide (PN),” extracted from salmon DNA. Polynucleotide is,It shares similar properties with human DNA and is less likely to trigger an excessive immune response.Features.
This treatment targets the delicate skin around the eyes, delivering a bouncy firmness and deep hydration from within. Among the Rejuran series, Rejuran Eye is specially formulated with a lower viscosity to suit the thin skin around the eyes, allowing it to blend naturally with the surrounding skin.
▼Learn more about Rejuran injections
How does it work on dark circles, fine lines, and loss of firmness under the eyes?
Rejuran Eye addresses the following complex concerns around the eyes to help restore a healthy appearance.
Dark circles under the eyes
There are three main types of dark circles under the eyes, and Rejuran Eye is designed to address each one based on its specific cause. For “blue dark circles,” where the skin is thin and blood vessels show through,By adding firmness, it makes blood vessels less visibleIt does. Also, for "brown under-eye circles" caused by dryness or uneven skin texture, it provides moisture toSupports healthy skin renewal. For "dark circles" caused by aging, providing plumpness and firmness helps minimize the appearance of the shadows, andAchieve a fresh, clean look around your eyesThere are times when
・Fine lines caused by dryness; loss of firmness
By replenishing the moisture that tends to diminish with age and helping the skin retain moisture, it minimizes the appearance of fine lines caused by dryness. It also firms the skin, leaving the eye area plump and hydrated.
Rejuran Eye is a treatment designed to support the skin's natural condition. Rather than producing dramatic results after a single session,We aim for a natural-looking result through a series of treatments.。
What You Need to Know About Downtime and Side Effects
Although Rejuran Eye is a procedure with relatively little downtime, the following symptoms may occur temporarily:
・Skin texture (unevenness)
The skin may temporarily swell after the Rejuran Eye injection. After the procedure,It generally takes a few hours to a few days for the skin to adjust and settle down.It is.
・Bruising and swelling
Since needles are inserted into the skin, temporary bruising, swelling, or redness may occur. While these reactions vary from person to person, they generally subside naturally over a period of a few days to a week, or up to about two weeks at most.
If you experience any symptoms that cause you concern—such as a strong sense of discomfort—please consult a doctor.
Differences from Hyaluronic Acid and Other Eye Area Treatments
In addition to Rejuran Eye, there are several other treatments designed to address the eye area. It’s important to understand the differences between them and choose the one that best suits your goals.
・Hyaluronic Acid Injections
Hyaluronic acid injections are a procedure in which medical-grade hyaluronic acid is injected into areas of concern, such as wrinkles or shadows, to physically plump and reshape the skin. While the visual results are easily noticeable, this treatment differs in purpose from approaches like Rejuran Eye, which aim to “improve skin condition by providing hydration.”
In addition, because the skin around the eyes is very thin, depending on the type of hyaluronic acid product used, the results may feel firm or appear bluish and translucent. For this reason, at Yayoi Clinic, we use products that blend more naturally with the skin for injections around the eyes,Features baby collagen for a natural-looking finishWe are doing so.
Botox
This treatment involves injecting Type A botulinum toxin (botulinum toxin) to temporarily relax muscle tension, thereby addressing wrinkles caused by facial expressions (such as laugh lines at the corners of the eyes). While it is effective for specific expression lines, it can also be a concern even when the face is expressionless.Rejuran Eye is ideal for addressing fine lines caused by dryness and a lack of firmness around the entire eye area, as it helps improve skin texture.。
▼Learn more about baby collagen, which is ideal for eye care
▼Learn More About Botox
3 Key Factors for Choosing a Rejuran Eye Clinic
Finally, to help you feel confident about getting Rijuran Eye treatment in Hiroshima, we’ve summarized three key points to consider when choosing a clinic.
Point 1: Is the pricing structure clear? Compare the total cost.
With Rejuran Eye, you’ll notice even better results by undergoing 3 to 4 treatments every 2 to 3 weeks. Therefore, it’s not just about the cost of a single session, but alsoIt's important to compare total costs based on the assumption that you'll visit multiple times.It is.
Also, check in advance whether the clinic’s website lists fees that include “consultation fees,” “anesthesia fees,” and “needle fees,” and whether there are any additional charges; choose a clinic that provides a clear estimate.
Point 2: Does the clinic have a team of reliable doctors with extensive clinical experience?
The skin around the eyes is very thin and delicate. Since the final results can vary significantly depending on the depth, volume, and placement of the injections, it is important to choose a doctor with extensive experience in injection treatments around the eyes.
The doctors’ backgrounds, credentials, and photos of actual cases featured on each clinic’s website and social media serve as a guide for assessing their credibility. At Yayoi Clinic, doctors with proven expertise carefully perform injections tailored to each patient’s individual condition.
Point 3: Is the counseling thorough and easy to talk to?
When choosing a clinic, look for one that provides a patient-centered consultation—one where the staff “listens to you with genuine care” and “thoroughly explains not only the benefits of the procedure but also the downtime and risks.” If the clinic avoids high-pressure sales tactics and offers recommendations tailored to your budget and preferences, you can entrust them with your treatment with confidence.
Get Rejuran Eye treatment in Hiroshima and achieve an eye area you can feel confident about
For those considering a Rejuran Eye treatment in Hiroshima, we’ve provided an explanation of the treatment’s features and answered some frequently asked questions. Since the appearance of the eye area greatly influences the overall impression of your face, it’s important to fully understand the treatment—including its risks—and find a clinic you can trust.
At Yayoi Clinic in Hiroshima City, where we perform Rejuran Eye treatments, we offer personalized consultations and pain-minimizing procedures. Please feel free to contact us for a consultation.
Aesthetic Dermatology, Aesthetic Medicine, Aesthetic Surgery, Art Make-up Yayoi Clinic (YAYOI CLINIC) in Hiroshima introduces treatments for different problems of the skin, body, and face.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
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Description of treatment] Rejuran
Recommended frequency of treatment: 3 to 4 times every 2 to 3 weeks / once every 6 months as maintenance.
Cost】¥58,000〜¥204,000 ※Prices vary depending on the area and number of times.
Side effects/risks] Pain, redness, swelling, internal bleeding
Equipment used.
Rejuran treatments include procedures using unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of procedure] Hyaluronic acid
Approximate number of treatments
Hyaluronic acid: per treatment
Hyaluronidase: 1-2 times
*The number of treatments for each of these varies from person to person.
Cost]
Hyaluronic acid: 1 unit ¥79,800 (+ ¥22,000 for the procedure fee) *The number of units used depends on the individual.
Hyaluronidase:
One time ¥33,000
Other hospitals: 1 time ¥55,000
Adverse effects/risks
Very rare side effects of hyaluronic acid have been reported, including transient or irreversible blindness, induced stroke, as well as nodules, beaded nodules, allergic reactions, granulomas, herpes, lack of or decreased correction, misalignment, necrosis, numbness, pain, tumors, infection, angioedema, discoloration and hematomas.
Side effects of hyaluronidase have been reported to include needle marks, internal bleeding, and allergic reactions.
If you notice any of these symptoms or any other abnormalities, please consult your doctor as soon as possible.
Equipment used.
Fillers and hyaluronidase injections include drugs not approved in Japan and treatments that differ from their approved regulatory use.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
Information on safety, etc. in other countries
-Juviderm Vista® series: approved in Japan for "correction of moderate to severe wrinkles and furrows on the face
-Hyaluronidase: Approved by MFDS, Korea
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of procedure] Botox injection
Recommended frequency of treatment] Once every 3 to 4 months *Return around 14 days after the peak effect.
Cost】・1 unit ¥649～¥869 (+ ¥22,000 for treatment fee) ※There are individual differences depending on the formulation and number of units used.
Adverse effects/risks
Headache, pain and swelling at injection site, partial muscle weakness, redness, bruising, skin tightness, numbness, prickling sensation, nausea, temporary dent, internal bleeding, difficulty swallowing, pneumonia, anaphylaxis, severe lethargy, etc.
Equipment used.
Botox treatment includes treatments that are either unapproved drugs in Japan or treatments that are different from those approved for use in the pharmaceutical industry.
Drugs and medical devices used for treatment were imported through a private importation procedure based on the judgment of a physician at our clinic.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance, except for those approved by the pharmaceutical affairs bodies.
Information on safety, etc. in other countries
-BOTOX VISTA® approved by the Japanese regulatory authorities for the treatment of expression lines between the eyebrows or at the corners of the eyes in adults under 65 years of age.
-NABOTA receives U.S. FDA approval
-CORETOX® receives Korea MFDS approval
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
