Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
Are you considering getting Rejuran injections in Hiroshima? Rejuran injections are a skin-rejuvenating treatment originating in South Korea, with salmon-derived polynucleotides (PN) as their main ingredient. This treatment enhances the skin’s natural vitality to help you achieve a healthy, radiant complexion. In this article, YAYOI CLINIC in Hiroshima will explain the basics of Rejuran injections, the procedure flow, and key points to keep in mind before and after treatment. If you’re interested in Rejuran injections, please use this as a reference.
What Is Rejuran? An Explanation from Yayoi Clinic in Hiroshima

For those wondering, “What is a Rejuran injection?” or “I want to know the effects of a Rejuran injection,” Yayoi Clinic in Hiroshima explains all about Rejuran.
■ Rijuran's Ingredients and Mechanism of Action
Rejuran is,A skin-nourishing injection developed in South Korea, with salmon-derived polynucleotides (PN) as its main ingredientIt is expected to stimulate the skin's natural functions and help achieve healthy, firm, and radiant skin.Works on fibroblasts—the building blocks of the skin—to support the production of collagen and hyaluronic acid. It also improves blood circulation and has anti-inflammatory properties, supporting skin health from the inside out.
■Differences from Conventional Cosmetic Injections
Rejuran and other cosmetic injections,The approach to skin care is different.. First, hyaluronic acid injections are a treatment in which the substance is injected under the skin in areas where a lack of volume is a concern to address wrinkles and sagging. While changes are often noticeable immediately after the procedure, the effects gradually fade. Botox injections, on the other hand, use botulinum toxin (type A) to relax muscle activity. They can help alleviate teeth grinding and treat or prevent expression lines, and patients typically notice results relatively sooner than with Rejuran.
■Expected Effects and Duration
Rejuran is said to activate fibroblasts and help treat fine lines around the eyes, dullness, dark circles, and acne scars.
Some of you may be wondering when Rejuran’s effects start to show and how long they last. While Rejuran doesn’t have immediate effects,You can start to see results 2 to 3 weeks after the treatment....will happen. Also, while the duration of the effects varies depending on skin type and lifestyle,A few months to about half a yearIt is.
In fact, some people may feel that “I had a Rejuran treatment, but it didn’t work.” This is because Rejuran does not produce immediate results; changes typically become apparent 2 to 3 weeks after the treatment. Additionally, depending on your skin condition, it may be difficult to notice changes right away. Especially with healthy skin, visible changes may seem minimal, but with regular treatments, you can expect to see an improvement in your skin’s texture.
Indications for Rejuran Injections and Expected Results
What kind of results can you expect from Rejuran injections? We’ll explain each one below.
■Fine Lines and Dark Circles Around the Eyes
Rejuran is an injectable treatment that reduces the appearance of fine lines caused by dryness and smooths the skin. When Rejuran is injected, it promotes skin renewal and stimulates the production of collagen, hyaluronic acid, and other substances that help maintain the skin’s moisture. As a result,It restores firmness and elasticity to the skin, making fine lines caused by dryness less noticeable.。
In addition, Rejuran is expected to be effective against dark circles under the eyes (blue circles) caused by poor blood circulation. By receiving Rejuran injections,Targets the cells under the eyes to promote blood flow. Furthermore, by supporting the functions of collagen and hyaluronic acid, you can achieve a brighter, more voluminous eye area.
■ Acne Scars & Pore Care
Rejuran injections are,It normalizes skin turnover and restores the skin's barrier function.. By controlling excess sebum production, you can also help tighten pores that tend to become enlarged. Therefore, this is a suitable option for those who are concerned about visible pores or recurring skin problems.
Furthermore, with repeated Rejuran treatments, your skin will become more radiant and smooth. Your skin’s overall firmness will improve, and acne scars will become less noticeable.
■ Addressing Dullness and Skin Texture
Polynucleotide, the main ingredient in Rejuran, is expected to help revitalize cells. As collagen is produced and skin turnover is promoted, the skin’s texture becomes more even and moisturized.As skin turnover normalizes, dullness is reduced and skin brightness improvesI will do so.
What You Should Know Before Getting Rejuran Injections in Hiroshima

Before getting a Rejuran injection, we’ll explain what you need to know—including the procedure and aftercare—using Yayoi Clinic in Hiroshima City as an example.
Treatment flow and time required
Here is an explanation of the procedure for Rejuran injections. At Yayoi Clinic in Hiroshima, we begin with a consultation to discuss your skin concerns and treatment goals. If you have any questions or concerns about Rejuran injections, please feel free to discuss them during the consultation. After examining your skin and confirming that Rejuran is suitable for you, we will recommend the appropriate treatment plan.
Before the procedure, we ask that you cleanse and wash your face to ensure your skin is clean. We will disinfect the desired injection site and inject Rejuran using a fine needle. To minimize discomfort during the injection, we offer anesthetic patches and local anesthesia. Please note that there is an additional charge for anesthesia. After the injection, we will confirm that bleeding has stopped, and the procedure is complete. The procedure time varies depending on the injection site, butApprox. 15 to 30 min.The first two are the following.
■Aftercare and Precautions
Since Rejuran is sometimes administered around the eyes or under the eyes, some people may be concerned about downtime. Because the solution is injected into the skin, the injection sites may swell slightly, butIn most cases, symptoms subside within a few hours to a day.. In addition, swelling, redness, or bruising may occur in the treated area—such as under the eyes—but these symptoms typically subside within 2 to 3 days, or at most about a week. Since the formulation is well-tolerated by the skin,Relatively short downtime...One of its characteristics is that it tends not to affect daily life. If your symptoms persist or you have any concerns, please consult a doctor.
As for aftercare, you may shower or bathe starting on the day of the procedure, but please avoid taking long baths. Please note that you should not apply makeup for 12 hours after the procedure. Additionally, for 1 to 2 weeks after the procedure, be sure to protect your skin from UV rays and keep it moisturized, and avoid touching the treated area or causing friction.
For consultations on Rejuran injections, visit Yayoi Clinic in Hiroshima
Yayoi Clinic in Hiroshima, which offers Rejuran treatments, has adopted a pain-minimizing method directly taught by BIANCA CLINIC in Ginza, Tokyo. Compared to traditional Rejuran injections, this method is recommended for those who are concerned about pain.
For the eye area, we use Rejuran i, which is the gentlest product in the Rejuran series and is ideal for treating fine lines around the eyes. This formulation is specifically designed for use around the eyes; it is formulated to blend easily with the thin skin in that area and is easy to apply even in areas where care must be taken to avoid blood vessels.
■ Conclusion.
For those interested in receiving Rejuran treatments in Hiroshima, we’ve explained the expected results, duration of effects, and precautions to take before and after the procedure. Rejuran is a skin-nourishing injection that enhances the skin’s natural vitality to promote a healthy, firm complexion. If you’d like to address fine lines and dark circles around the eyes, improve firmness in the eye area, or are concerned about dullness, please feel free to contact Yayoi Clinic.
Aesthetic Dermatology, Aesthetic Medicine, Aesthetic Surgery, Art Make-up Yayoi Clinic (YAYOI CLINIC) in Hiroshima introduces treatments for different problems of the skin, body, and face.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
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Description of treatment] Rejuran
Recommended frequency of treatment: 3 to 4 times every 2 to 3 weeks / once every 6 months as maintenance.
Cost】¥58,000〜¥204,000 ※Prices vary depending on the area and number of times.
Side effects/risks] Pain, redness, swelling, internal bleeding
Equipment used.
Rejuran treatments include procedures using unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.