Dr. Yayoko Ito
Profile
Graduated from Hiroshima University School of Medicine. After working in the Department of General Medicine, he studied under doctors at the forefront of cosmetic medicine. After acquiring knowledge and skills in aesthetics, he became the director of YAYOI CLINIC in 2023. Her specialties include Botox, hyaluronic acid injections, and customized sagging treatment. His motto is to provide natural and pain-free treatments with careful consultation.
Are you considering getting PROFHILO® in Hiroshima? PROFHILO® is a formulation created using a special technique that combines two types of hyaluronic acid with different molecular sizes. In this article, we’ll explain PROFHILO®’s features, effects, differences from conventional hyaluronic acid injections, the treatment process, and important precautions for those considering PROFHILO® in Hiroshima. This is a must-read for anyone looking to learn more about PROFHILO®.
What Is Profilo? An Explanation from Yayoi Clinic in Hiroshima

From here on, YAYOI CLINIC in Hiroshima will explain what Profilo is.
■ Features and Expected Effects of Profilo
Profilor is a product developed by the Italian company IBSA. It features a unique blend of two types of non-crosslinked hyaluronic acid—low-molecular-weight and high-molecular-weight—using a technology called NAHYCO™.Injecting Profhilo into the skin is expected to improve skin firmness and elasticity.Yes, it can. Since this treatment addresses the overall texture of the skin, it is ideal for those concerned about age-related loss of firmness and dryness.
Unlike conventional cross-linked hyaluronic acid formulations, Profilo does not use a cross-linking agent but instead contains a stable formulation of non-cross-linked hyaluronic acid.One of its characteristics is that it spreads easily across the skin after injection, allowing for natural-looking results.. Since it does not contain a cross-linking agent, compared to conventional cross-linked hyaluronic acid formulations,Makes it easier to accommodate people with allergiesAnother feature is its texture. It has a soft texture and spreads naturally over the entire skin with just a small amount, so fewer needle insertions are needed.
While Profilo has many benefits as described above, its drawbacks include:In addition to the risk of bruising, the cost is relatively high.These are some key points you should be aware of. If you have any concerns about risks or costs, please feel free to consult with us during a counseling session.
■Differences from Conventional Hyaluronic Acid Injections
Conventional hyaluronic acid injections are a procedure in which the substance is injected into areas of concern—such as wrinkles around the eyes and nasolabial folds—to restore volume, thereby making wrinkles and sagging less noticeable. While patients often notice results immediately after the injection, the effects are short-lived because the substance is absorbed by the body. Additionally, it does not promote skin regeneration.
In contrast, Profhilo supports the production of collagen and elastin and works on the skin’s foundation, which can help improve the overall firmness and elasticity of the skin. Rather than physically filling in wrinkles and depressions like traditional hyaluronic acid injections,One of its key features is that it makes it easy to naturally even out the texture of the entire faceThat's right. The effects of Profhilo gradually become apparent over the course of several weeks after the treatment.
The Procedure and Precautions for Profhilo

In the following section, we’ll explain the procedure flow and precautions for Profhilo, using Yayoi Clinic in Hiroshima as an example.
■ Importance of pre-counseling
When undergoing Profhilo treatment, be sure to communicate your preferences during the pre-treatment consultation so you won’t have any regrets, andIt's important to clear up any questions you may haveThat’s right. You should decide whether to undergo Profhilo treatment after considering how it differs from standard hyaluronic acid injections and from other procedures. At Yayoi Clinic in Hiroshima, where Profhilo is available, a doctor will propose a treatment plan tailored to each patient’s skin condition and concerns during the consultation. Be sure to ask any questions you may have about pain or the treatment itself in detail at this time.
■Treatment Procedure and Duration
We’ll determine the treatment plan during your consultation, and once you’re satisfied with it, we’ll proceed with the procedure. For those concerned about pain during the Profhilo treatment, we’ll use a vibrating pen or numbing cream to minimize discomfort. Once you’re ready, we’ll inject Profhilo using ultra-fine needles. Typically, treatments for the face (entire face) or neck involve around 10 injection sites, and the estimated treatment time is15 to 30 minutesThat's correct. However, treatment time varies depending on the type and scope of treatment.
■ Post-treatment care and precautions
You may take a light bath or wash your face starting on the day of the procedure. Also, immediately after the Profhilo treatment, you may feel a lump-like sensation at the injection site, but this will gradually subside over time.Avoid stimulating the treated area by rubbing it or touching it too firmly.。
Please refrain from drinking large amounts of alcohol, using a sauna, or engaging in strenuous exercise on the day of your treatment, as these activities increase the risk of bruising. You may apply makeup starting the day after your treatment, but please avoid the treated area.
Indications for Profhilo and Expected Results

Here, we explain what symptoms Profilo is expected to be effective for.
■Sagging and wrinkles
Profhilo is a treatment that is expected to be effective for sagging and loose skin on the cheeks, fine lines around the eyes and on the cheeks, nasolabial folds, and marionette lines. By injecting it evenly into multiple areas, it helps improve the overall firmness and elasticity of the skin. Additionally,Injections can also be administered into the lines and wrinkles on the backs of the hands, where signs of aging are most noticeableThis helps you achieve hands with a natural, radiant glow. In addition, the treatment can be applied to the neck, where it can help reduce fine lines and improve firmness.
■Improving Skin Texture and Firmness
Prophilo improves skin texture, firmness, and radiance by supporting the production of collagen and elastin within the skin. It also addresses dullness, leading to an overall improvement in skin quality.
■Dark Circles Under the Eyes
Profhilo can also be effective in reducing the appearance of dark circles under the eyes. With traditional Botox (Botulinum Toxin Type A) injections or hyaluronic acid injections,Treatment is now possible under the eyes—an area that was previously difficult to treatAs a result, it can address both blue under-eye circles caused by age-related thinning of the skin and dark under-eye circles caused by mild sagging.
For consultations regarding Profhilo, visit Yayoi Clinic in Hiroshima
If you’re interested in receiving Profhilo treatment in Hiroshima, please consult Yayoi Clinic. At Yayoi Clinic, we carefully identify the root cause of your concerns and then propose a treatment plan tailored to each client’s skin condition and preferences. We’ll guide you toward the treatment that best suits your needs, taking into account your budget, acceptable downtime, and the desired pace of the procedure.
If you are concerned about pain during your Profhilo treatment, please be sure to discuss this with us during your consultation. We will tailor the treatment to minimize your discomfort.
■ Conclusion.
Yayoi Clinic in Hiroshima has provided an explanation of Profhilo. Unlike traditional hyaluronic acid injections, Profhilo is a treatment that supports the mechanisms responsible for skin firmness and elasticity. It is considered a next-generation hyaluronic acid treatment that goes beyond simply injecting the problem areas; it addresses the overall texture and firmness of the skin. If you’re interested in trying Profhilo in Hiroshima, please feel free to schedule a consultation at Yayoi Clinic.
Aesthetic Dermatology, Aesthetic Medicine, Aesthetic Surgery, Art Make-up Yayoi Clinic (YAYOI CLINIC) in Hiroshima introduces treatments for different problems of the skin, body, and face.
In order to provide you with the best option, we will assess each individual's skin condition and formulate a treatment plan that meets your needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
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[Description of treatment] Profilo
Approximate number of treatments
Initial: 2 times at 1 month intervals
After the second time: once every six months
*The number of treatments depends on the skin age.
Cost] ¥82,000 - ¥158,400 *Prices vary depending on the number of times.
Side effects/risks] Pain at the injection site, inflammation, redness, itching, swelling, internal bleeding, allergic reaction due to body constitution, etc.
Equipment used.
Profibro's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.