Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
Plureal is a skin-nourishing treatment that revitalizes the skin. In this article, we’ll provide an easy-to-understand explanation of the Plureal treatment process, its three key active ingredients, treatment frequency, and downtime. If you’re interested in learning more about Plureal, this is a must-read.
What is Plural?

Pural is a skin-nourishing formula that helps maintain the skin's moisture and firmness.It supports the skin's natural self-repairing ability and enhances moisture levels, firmness, and elasticity.。
[Feature 1 of Pulreal]
Formulated with a blend of ingredients such as hyaluronic acid, mannitol, and polynucleotides. Their synergistic effects work together to effectively improve skin texture.
[Feature 2 of Pulreal]
The dermis is the key to healthy skin. Plural is thatInjecting ingredients directly into the dermis. By promoting collagen production, it enhances the volume of the dermis to address severe dryness and wrinkles.
[Feature 3 of Pulreal]
Prurial is a formulation that promotes healthy skin and has anti-inflammatory properties. It is expected to help suppress inflammation and is gaining attention as a treatment designed to address redness and skin irritation caused by dryness.
The best of both Rijuran and Sunecos!

There are three main ingredients in Pulreal.
Non-cross-linked hyaluronic acid
It enhances the skin's moisture retention and elasticity, leading to smoother skin.
■Polynucleotides (PN)
Also known as the “salmon injection.” It boosts collagen production and enhances the skin’s ability to repair and regenerate itself, resulting in plump, supple skin.
■Mannitol
It helps reduce swelling and slow down the breakdown of hyaluronic acid, allowing you to maintain moisturized, supple skin.
Thanks to the combination of these ingredients, PurualOne bottle offers a variety of benefitsYes, it can. This biomodeling formulation is designed to help you achieve anti-aging benefits and beautiful skin efficiently. It is gaining attention as a formulation that combines the characteristics of the ingredients found in Rejuran and Snekos.
Plural is recommended for people like this!

Prural is suitable for people who:
- I'm concerned about dry skin
- I want to boost my skin's moisture levels and achieve firm, radiant skin.
- I'm concerned about fine lines
- I'm concerned about redness and uneven skin tone
For full-face treatments,We recommend using one vial. Plural'sDowntime is about one weekIt is.
While some people notice a difference in their skin after just one treatment, continuing to receive Plurial injections once every 2 to 3 weeks helps the effects last longer.
For Plural, visit YAYOI CLINIC
Plural is a skin-nourishing formula designed to address skin concerns such as lack of moisture and firmness, fine lines, and dryness. With a blend of hyaluronic acid, polynucleotides, and mannitol, it aims to promote healthy skin from within.
At Yayoi Clinic, we recommend treatments tailored to each individual’s skin condition and concerns. If you’re concerned about dry skin or a loss of firmness, please feel free to consult with us.
Aesthetic Dermatology, Cosmetic Medicine, Cosmetic Surgery, Art Makeup in Hiroshima YAYOI CLINIC offers treatments for different skin, body, and facial concerns.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
Description of treatment] Pull Real
Approximate number of treatments] Once every 2 to 3 weeks (1 course: about 3 treatments) *Treatment intervals vary depending on skin conditions.
Cost] ¥71,000 - ¥204,000 *Prices vary depending on the area and number of times.
[Side effects/risks] Post-treatment bleeding, edema, erythema without swelling, redness, swelling, itching, hematoma, tenderness, etc.
Equipment used.
Pluryal treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from MD Skin Solutions, Inc. under the judgment of our doctors.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
-All products are CE certified in Europe.
About the Adverse Reactions Relief System for Drugs
-In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief Program.