Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
We’ll explain what “Mesona J”—a device currently making waves in the beauty industry—is all about, including how long its effects last and any potential drawbacks. Also, be sure to check out the chemical hair colors available at YAYOI CLINIC, as well as the effects of our new “Orange” shade.
What is MESONA J

■What is Mesona J?
A transdermal delivery device designed exclusively for medical devices, intended to deliver active ingredients such as vitamin C and collagen to the stratum corneumIt is.
The color of the medication varies depending on the combination of active ingredients. At YAYOI CLINIC, we offer pink, yellow, white,Newly Introduced Orange...You can choose the one that best suits your skin concerns and preferences.
・Fees
At YAYOI CLINIC, the price for Mesona J starts at ¥19,800 for new patients and ¥21,780 for regular patients. Other treatments include anti-aging care (full treatment) at ¥32,780 and spot treatment (optional) at ¥2,200. Please see the price list on our website for more details.
■ Things to Keep an Eye On at Mesona J
・Duration
The duration of Mesona J's effects varies from person to person, butThe longer you continue with the treatments, the longer the effects are likely to last.. Even a single session can help improve your skin texture, but it typically takes several sessions to notice a real difference. Don’t assume there are no results immediately after the treatment;Receive treatment once a month for about 3 to 4 monthsThis makes it easier to improve the condition of your skin.
・Mesona J from YAYOI CLINIC
In addition to electroporation—which uses electrical stimulation—the Mesona J at YAYOI CLINIC is equipped with a roller probe that utilizes electrical repulsion and penetration. Unlike conventional electroporation,Designed to help active ingredients penetrate the stratum corneumThe company has been
・What's the difference between this and CareSys?
The difference from CareSys devices is that CareSys is a device designed exclusively for medical institutions that features heating and cooling functions (45°C to -20°C). Applying the product while warming the skin opens the pores, andIt is characterized by its ability to easily deliver active ingredients to the stratum corneum. It is believed that cooling causes blood vessels to constrict, allowing the active ingredients to remain in the skin for a longer period of time.
・What are the downsides?
As for the downsides of Mesona J,Side effects may occur, and allergic reactions to the medication may cause redness, itching, swelling, and other symptoms.. If you have any allergies (to metals, cosmetics, medications, foods, etc.), please let us know in advance.
・Customer Reviews
Reviews of the effects of YAYOI CLINIC’s Mesona J include comments such as, “The redness in my skin has subsided,” and “It’s almost painless and easy to undergo.”
The Effects of Mesona Orange

■ Expected Effects by Color
The newly introduced "Orange" is,Treating redness and acne; enhancing radiance and firmness。
Main Medications
BIO VISO V2 (Vitamin B2), BIO 12 (Main Ingredient: ACB12)
At YAYOI CLINIC, in addition to the two main medications, you can choose either “tranexamic acid,” which is expected to inhibit melanin production and have anti-inflammatory effects, or “vitamin C derivatives,” which boost collagen production and help achieve a brighter complexion, to combine with your treatment.
The Effects of Mesona Pink, Yellow, and White

■ Expected Effects by Color
"Pink" helps treat redness and acne.
Main Medications:
BIO VISO (with squalane), BIO12 (vitamin B12)
"Yellow" enhances skin radiance and firmness.
Main Medications:
BIO VISO V2 (Vitamin B2), BIO 10 (Coenzyme Q10)
"White" helps treat dark spots and dullness.
Main Medications:
BIO VISO (with squalane), BIO 10 (Coenzyme Q10)
For Mesona J, visit YAYOI CLINIC
Mesona J is a treatment designed to deliver beauty ingredients down to the stratum corneum by combining active ingredients tailored to specific skin concerns. Another key feature is its ability to customize the treatment to each individual’s unique skin condition, such as redness, dryness, or loss of firmness.
At Yayoi Clinic, we offer treatments using pink, yellow, white, and orange formulations, and we’ll recommend a treatment tailored to your concerns and preferences. If you’re interested in Mesona J, please feel free to contact us.
Aesthetic Dermatology, Cosmetic Medicine, Cosmetic Surgery, and Art Makeup in Hiroshima YAYOI CLINIC offers treatments for different problems of the skin, body, and face.
In order to offer a better option to our customers, we will assess the skin condition of each individual and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
[Description of treatment] Mesona J.
Approximate number of treatments] Once every 4 weeks (1 course: about 4 to 6 treatments) *Depends on the treatment.
Cost】 ¥21,780~ ¥32,780
Adverse effects/risks
Redness, heat, itching, swelling, and rashes may occur due to allergic reactions to the drugs used.
In rare cases, some patients may feel a tingling sensation during the treatment. Please let us know if this is the case.
There may be a taste sensation of iron in the mouth and a flash of light due to the procedure near the eyes, but this is not a problem.
Equipment used.
Treatment of Mesotherapy includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical equipment used for treatment were purchased from SeleneMedical, Inc. under the judgment of our physicians. Please refer to the right column for information on drugs and other items of note for personal purchase. https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in Japan
The following certifications have been obtained
Safety standard JIS-T 0601-1 (IEC60601-1:2005)
Electromagnetic compatibility (EMC) IEC60601-1-2:ed3
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.