Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
ECM treatments, which are currently gaining attention, are a form of cosmetic medicine designed to improve skin quality by enhancing firmness, elasticity, and hydration. Yayoi Clinic offers three types of ECM treatments, each with different ingredients and approaches tailored to specific skin concerns. In this article, we’ll explain the features and pricing of these three treatments. Be sure to read on to the end.
Let's Check the Effectiveness of ECM Formulations
ECM (extracellular matrix) formulations are medications that act on the ECM to improve the skin’s elasticity and refine its texture. The ECM (extracellular matrix) is,Non-cellular tissue that fills the spaces between cells, such as collagen and elastinECM formulations promote the production of collagen, elastin, and other substances, and enhance the elasticity of the dermis, which forms the foundation of the skin.
ECM formulations are sometimes classified under the same category of skin-nourishing treatments as PN formulations and PDLLA formulations, but their mechanisms of action differ.
Yayoi Clinic offers three ECM products!
At Yayoi Clinic, we offer three types of ECM preparations.
〈Sunecos〉
Main Ingredients: Non-crosslinked hyaluronic acid, 6 types of amino acids
Features: It has a light, smooth texture, andA natural finish even on areas with thin skinbecome
〈Profilro〉
Main Ingredients: Two types of hyaluronic acid with different molecular weights
Features:It can reach down to the fat layer beneath the dermis,, helping your skin become plump and more elastic
〈Hydro〉
Main Ingredients: Three types of hyaluronic acid with different molecular weights
Features: Because it combines three types of hyaluronic acid,It possesses strong cell-activating and cell-regenerating properties
How to Choose the Right ECM Formulation
Next, I will explain how to choose between the three ECM formulations.
〈Sunecos〉
Recommended for specific concerns like fine lines!
- Horizontal wrinkles on the forehead
- Neck wrinkles
- Fine lines around the eyes
- Dark circles under the eyes
〈Profilro〉
Recommended for those who want plump, firm skin!
- laugh lines
- wrinkle
- Cheek Hollows
- slack
〈Hydro〉
Recommended for anyone looking to reduce wrinkles or achieve a more lifted appearance!
- Wrinkles around the eyes and mouth
- Neck wrinkles
- Stretch Marks
Please also refer to the comparison table below.
| Formulation | main ingredient | Common Concerns |
| SUNEKOS® | Uncrosslinked HA + Amino Acids | fine wrinkles |
| Profhilo (PROFHILO®︎) | Hybrid HA | Firmness and Sagging |
| Hydro Injections | 3 Types of HA | Wrinkles & Moisturizing |
Check the prices of ECM formulations
Finally, here are the prices for the ECM preparations offered at Yayoi Clinic.
〈Sunecos〉
Around the eyes 3 times
Regular Price: 131,800 yen (tax included)
4 sessions for the entire face
Regular Price: 175,780 yen (tax included)
〈Profilro〉
Face or neck (2 times)
Regular Price: 158,400 yen (tax included)
〈Hydro〉
one's whole face
Regular Price: 77,000 yen (tax included) – Full Face + Neck
Regular Price: 130,900 yen (tax included)
Each ECM treatment has its own characteristics, pricing, and recommended uses. Compare the options to choose the one that best suits your skin condition and desired results.
For ECM formulations, visit YAYOI CLINIC
ECM formulations are skin-nourishing treatments designed to address common skin concerns that tend to arise with age, such as firmness, elasticity, and hydration. Since each formulation has different characteristics and is suited for different concerns, it’s important to choose one that matches your skin condition and desired results.
At Yayoi Clinic, we offer three types of ECM products—Snecos, Profilo, and Hydro—and tailor our recommendations to each patient’s specific concerns. If you’re unsure which ECM product is right for you, please feel free to consult with us.
Aesthetic Dermatology, Cosmetic Medicine, Cosmetic Surgery, and Art Makeup in Hiroshima YAYOI CLINIC offers treatments for different problems of the skin, body, and face.
In order to offer a better option to our customers, we will assess the skin condition of each individual and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
Description of treatment] Snechos
Approximate number of treatments] Once every 2 weeks x 3-4 times (1 course) *Depends on the treatment.
Cost] ¥128,000 - ¥175,800 *Prices vary depending on the area and number of times.
Side effects/risks] bleeding, redness, swelling, tenderness, pain, itching, mild/moderate bruising, mild edema, internal bleeding, etc.
Equipment used.
Snekos treatment includes the use of unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
-The special ratio of amino acids in the drug has been patented internationally by an Italian development company.
-CE Mark Class III (European safety standard conformity approval)
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
[Description of treatment] Profilo
Approximate number of treatments
Initial: 2 times at 1 month intervals
After the second time: once every six months
*The number of treatments depends on the skin age.
Cost] ¥82,000 - ¥158,400 *Prices vary depending on the number of times.
Side effects/risks] Pain at the injection site, inflammation, redness, itching, swelling, internal bleeding, allergic reaction due to body constitution, etc.
Equipment used.
Profibro's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Hydro
Approximate number of treatments: 3-4 times every 2 weeks
Cost] ¥71,000 - ¥204,000 *Prices vary depending on the area and number of times.
Adverse effects/risks
Tingling, itching, redness, and heat may occur for about 2 days after treatment.
Swelling may remain for 1-2 days and internal bleeding for about 7 days, but usually resolves spontaneously.
Depending on the individual and the injection site, the puffiness may remain for 1-3 days after treatment. It will settle naturally as the drug is diffused.
Equipment used.
Hydro treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Obtained European CE Mark[p1].
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
