Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
Do you know the difference between non-cross-linked hyaluronic acid and cross-linked hyaluronic acid? In fact, different formulations of hyaluronic acid are suitable for different areas and have different effects. Learn more about the formulations and procedures to find the hyaluronic acid injections that best suit your concerns.
What is the difference between cross-linked hyaluronic acid and non-cross-linked hyaluronic acid?
There are two types of hyaluronic acid, "cross-linked" and "non-cross-linked," and there are differences in suitable areas and procedures. Cross-linking is a process used to link hyaluronic acid together. Let's take a look at the characteristics of each.
■ Cross-linked hyaluronic acid
Cross-linked hyaluronic acid is hard and is not easily degraded by the body,Suitable for increasing volume。
Non-cross-linked hyaluronic acid
Non-cross-linked hyaluronic acid is soft, spreadable, and easily blended,Effective in retaining skin moisture and improving skin textureIt is.
Cross-linked Hyaluronic Acid Preparation Usage
Yayoi Clinic's hyaluronic acid injections use different cross-linked formulations depending on the injection site and effect. Hyaluronic acid isThe more cross-links, the harder and longer the duration tends to beThere are
Here are the injection sites, effects, and durations of the five cross-linked hyaluronic acid formulations.
■Voluma XC
Injection sites are temples, cheeks, face line and chin. The effect of volume enhancement isLasts about 18-34 monthsIt has a relatively long duration among the five formulations.
■Borax XC
It is mainly injected into the face line and chin. It is used for contouring and lasts forAbout 18 monthsOf the five, this is the hardest formulation with more cross-linking.
■BOLIFT XC
It can be injected into the laugh lines and around the mouth to improve wrinkles. Duration.About 12 to 18 monthsIt is.
■Volvera XC
It is suitable for injection into the entire face, under the eyes and lips. The effect is to improve wrinkles, depressions, and increase volume.About 12 monthsSustained.
■Bolite XC
Injection sites include the entire face and neck. It improves skin texture and lasts for a long time.4 to 9 monthsIt is the softest and shortest lasting formulation of the five.
Treatment with non-cross-linked hyaluronic acid and hybrid hyaluronic acid
In addition to non-cross-linked hyaluronic acid, Yayoi Clinic also offers procedures using hybrid hyaluronic acid.
First, we will introduce three types of procedures that use non-cross-linked hyaluronic acid preparations suitable for skin moisture retention and skin texture improvement.
■Snechos
SUNECOS is an injection procedure that uses a formulation of six amino acids and non-cross-linked hyaluronic acid that provides firmness. The soft, non-cross-linked hyaluronic acid is the reason for this,Can be injected into thin and fine skin areas such as wrinkles around the eyesThe skin is left with a natural finish and a feeling of firmness and elasticity. It is designed for skin that feels firm and elastic with a natural finish.
■Jubeluk
JUVELUX approaches acne scars and pores with polylactic acid and non-cross-linked hyaluronic acid, which stimulate collagen production.Duration is relatively long, absorbed in the skin over 1-2 yearsThe treatment is performed on the patient's own body. It is also possible to concentrate on areas of concern and customize the amount of injections.
■Purreal
Plurial suitable for rosacea (rosacea) and redness problems. Mainly polynucleotides extracted from salmon and trout, which are high in antioxidants,Injection of a drug containing non-cross-linked hyaluronic acid and mannitolIt is. It will stimulate collagen production in the skin and make it more supple.
Next, we will introduce two procedures using hybrid hyaluronic acid preparations. Hybrid hyaluronic acid is a specially processed combination of hyaluronic acids of different molecular weights.
■Profilo
PROFILO is a formulation containing two types of hyaluronic acid with different molecular sizes. It can be injected into the neck and back of the hands,Approaches fat cells and other cells that form the foundation of the skinIt leads to plump skin with a sense of firmness and elasticity.
■Hydro
Hydro is a combination of three types of hyaluronic acid. Unlike volumizing and contouring procedures, HydroInjection supports collagen production in the skinThe treatment is performed on the face and neck. This treatment is expected to improve the elasticity of the aging face and neck.
For hyaluronic acid injections, visit YAYOI CLINIC
We have introduced the difference between non-cross-linked hyaluronic acid and cross-linked hyaluronic acid and the characteristics of injection procedures using each formulation. Non-cross-linked hyaluronic acid is suitable for improving skin texture and firmness, while cross-linked hyaluronic acid is suitable for contouring and volume enhancement. When injecting hyaluronic acid, choose the formulation and procedure that best suits your concerns.
Aesthetic Dermatology, Cosmetic Medicine, Cosmetic Surgery, Art Makeup in Hiroshima YAYOI CLINIC offers treatments for different skin, body, and facial concerns.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
Description of procedure] Hyaluronic acid
Approximate number of treatments
Hyaluronic acid: per treatment
Hyaluronidase: 1-2 times
*The number of treatments for each of these varies from person to person.
Cost]
Hyaluronic acid: 1 unit ¥79,800 (+ ¥22,000 for the procedure fee) *The number of units used depends on the individual.
Hyaluronidase:
One time ¥33,000
Other hospitals: 1 time ¥55,000
Adverse effects/risks
Very rare side effects of hyaluronic acid have been reported, including transient or irreversible blindness, induced stroke, as well as nodules, beaded nodules, allergic reactions, granulomas, herpes, lack of or decreased correction, misalignment, necrosis, numbness, pain, tumors, infection, angioedema, discoloration and hematomas.
Side effects of hyaluronidase have been reported to include needle marks, internal bleeding, and allergic reactions.
If you notice any of these symptoms or any other abnormalities, please consult your doctor as soon as possible.
Equipment used.
Fillers and hyaluronidase injections include drugs not approved in Japan and treatments that differ from their approved regulatory use.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
Information on safety, etc. in other countries
-Juviderm Vista® series: approved in Japan for "correction of moderate to severe wrinkles and furrows on the face
-Hyaluronidase: Approved by MFDS, Korea
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Snechos
Approximate number of treatments] Once every 2 weeks x 3-4 times (1 course) *Depends on the treatment.
Cost] ¥128,000 - ¥175,800 *Prices vary depending on the area and number of times.
Side effects/risks] bleeding, redness, swelling, tenderness, pain, itching, mild/moderate bruising, mild edema, internal bleeding, etc.
Equipment used.
Snekos treatment includes the use of unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
-The special ratio of amino acids in the drug has been patented internationally by an Italian development company.
-CE Mark Class III (European safety standard conformity approval)
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
[Description of treatment] Jubeluk
Approximate number of treatments
Fine wrinkles: 1-2 times per month
Skin texture improvement: about twice per month
Acne scars: about 3 times per month
*Depends on the condition of the skin.
Cost: ¥55,000-199,800 per session
Adverse effects/risks
Redness, swelling, and swelling at the injection site
Equipment used.
JUVELEC's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
U.S. Food and Drug Administration (FDA)
Ministry of Food and Drug Safety of Korea (MFDS)
CE Medicines in Europe
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Pull Real
Approximate number of treatments] Once every 2 to 3 weeks (1 course: about 3 treatments) *Treatment intervals vary depending on skin conditions.
Cost] ¥71,000 - ¥204,000 *Prices vary depending on the area and number of times.
[Side effects/risks] Post-treatment bleeding, edema, erythema without swelling, redness, swelling, itching, hematoma, tenderness, etc.
Equipment used.
Pluryal treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from MD Skin Solutions, Inc. under the judgment of our doctors.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
-All products are CE certified in Europe.
About the Adverse Reactions Relief System for Drugs
-In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief Program.
[Description of treatment] Profilo
Approximate number of treatments
Initial: 2 times at 1 month intervals
After the second time: once every six months
*The number of treatments depends on the skin age.
Cost] ¥82,000 - ¥158,400 *Prices vary depending on the number of times.
Side effects/risks] Pain at the injection site, inflammation, redness, itching, swelling, internal bleeding, allergic reaction due to body constitution, etc.
Equipment used.
Profibro's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Hydro
Approximate number of treatments: 3-4 times every 2 weeks
Cost] ¥71,000 - ¥204,000 *Prices vary depending on the area and number of times.
Adverse effects/risks
Tingling, itching, redness, and heat may occur for about 2 days after treatment.
Swelling may remain for 1-2 days and internal bleeding for about 7 days, but usually resolves spontaneously.
Depending on the individual and the injection site, the puffiness may remain for 1-3 days after treatment. It will settle naturally as the drug is diffused.
Equipment used.
Hydro treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Obtained European CE Mark[p1].
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
