Dr. Yayoko Ito
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Graduated from Hiroshima University School of Medicine. After working in the Department of General Medicine, he studied under doctors at the forefront of cosmetic medicine. After acquiring knowledge and skills in aesthetics, he became the director of YAYOI CLINIC in 2023. Her specialties include Botox, hyaluronic acid injections, and customized sagging treatment. His motto is to provide natural and pain-free treatments with careful consultation.
Are you considering getting a manual Rejuran (polynucleotide) injection treatment in Hiroshima? Rejuran treatments can be administered either manually—where a doctor injects the solution directly—or using specialized equipment, and each method offers different benefits. In this article, YAYOI CLINIC, a cosmetic dermatology clinic in Hiroshima, explains the characteristics of manual Rejuran treatments and offers tips to help alleviate any concerns you may have. If you’re hoping to achieve clear, healthy skin with Rejuran, we encourage you to read on.
FAQs You Should Know Before Undergoing a Rejuran Injection | Hiroshima Yayoi Clinic
For those who are concerned—asking questions like, “Does the injection hurt?” or “I’d like to try Rejuran administered by hand, but how effective is it?”—Hiroshima Yayoi Clinic answers these common questions.
■ How much does it hurt during the procedure? Is anesthesia available?
Since the Rejuran manual injection procedure uses ultra-fine needles to inject the solution little by little,It is accompanied by a prickling sensation.. If you'd like to undergo treatment with minimal discomfort, pleaseApplying a topical anesthetic (anesthetic cream) can help alleviate discomfort.I am sure you will.
The Rejuran manual injection treatment at Hiroshima Yayoi Clinic uses medications formulated with pain management in mind. Anesthesia is also available, so if you’re concerned about pain, please feel free to discuss it with us during your consultation.
■How many sessions are needed to see results?
Some people notice improved skin firmness and hydration after just one Rejuran treatment. However, to fully bring out the treatment’s benefits, it is recommended to undergo multiple sessions over time. Results may vary depending on individual skin conditions, butGenerally speaking, undergoing a total of 3 to 4 treatments at a rate of once every 2 to 3 weeks tends to help improve the skin's condition.I am sure you will.
After that, continuing with maintenance treatments about once every few months will make it easier to maintain healthy skin. Since the appropriate number of treatments and frequency vary depending on your skin condition and age, you should first consult with your doctor to discuss a long-term schedule.
■ Can I wear makeup or take a bath on the day of the procedure?
After the procedure, swelling may occur at the injection site. This usually subsides within a few hours to about one day, but since we need to monitor the situation,Please avoid wearing makeup for 12 hours after your treatment.. You can start wearing makeup again the next day.You may bathe and wash your face starting on the day of the procedure, but please be careful not to scrub the treated area too vigorously.Please note that swelling, redness, and bruising may occur for a few days. Also, since your skin will be sensitive after the procedure, be sure to moisturize thoroughly and protect your skin from UV rays.
■What's the difference between Rejuran and the HydraFacial?
Hiroshima Yayoi Clinic explains the difference between Rejuran and hydrafacial treatments—two options people often struggle to choose between when looking to improve skin firmness and radiance. Hydrafacial treatments primarily use a specialized stamp-type device,Delivers beauty ingredients evenly to the skin, providing overall hydration and radianceThis is a treatment. On the other hand, Rejuran delivers polynucleotides derived from salmon to support the skin’s natural functions, addressing firmness and elasticity from the foundation up. If you’re looking for an overall glow, the HydraFacial is the better choice; if you’re seeking fundamental skin health and fine line care, Rejuran is the better option.
■What is the difference between Rejuran and hyaluronic acid injections?
Hyaluronic acid isWith just one injection, it can lift facial features, add volume, and—thanks to its ability to temporarily retain moisture—create a noticeable transformation.This is a treatment. On the other hand, Rejuran supports the skin’s natural functions, allowing it to naturally improve skin firmness and elasticity. It’s also effective for treating wrinkles and fine lines, and you can expect a natural-looking result that doesn’t appear overly treated.
▼ [Rejuran] Check the treatment features and price list at Hiroshima Yayoi Clinic
To Avoid Regrets! How to Choose a Clinic for Hand-Administered Rejuran in Hiroshima
With manual injections, the doctor’s skill in making precise adjustments to the injection volume and depth affects the final results. In the following section, Hiroshima Yayoi Clinic explains how to choose a clinic that will ensure you’re satisfied with your Rejuran treatment—so you won’t have any regrets.
■Does the clinic have a team of trusted doctors with extensive clinical experience?
The manual administration of Rejuran is a delicate procedure in which the injection angle and volume are controlled for each individual injection based on the patient’s facial bone structure and skin thickness. For this reason, the treating physician’s level of experience and number of cases treated are key factors in the decision-making process.Check photos of actual cases posted on the official website and social media to see the beautiful results and review the doctor’s background.Let's do it. It's also helpful to consider whether the doctor is board-certified and whether they specialize in injection treatments on a regular basis.
■ Is the pricing structure clear? Compare based on the total cost
Since multiple, ongoing treatments are recommended for Rejuran, it’s important to consider not only the cost per session but alsoIt's important to figure out how much it will cost in total.Please note that even if you search for something like “affordable Rejuran aesthetic treatments in Hiroshima,” the total cost could still end up being high.
In addition to the cost of the medication itself, some clinics charge separate fees for the initial consultation, follow-up visits, topical anesthesia, and the option to switch to ultra-fine needles. Be sure to ask during the consultation whether they will provide a total estimate that includes all necessary supplies.
■Can I discuss my concerns in depth during counseling?
To ensure you feel confident about undergoing treatment, pay close attention to the quality of the initial consultation. Look for a clinic where doctors carefully examine each patient’s skin condition. Don’t just focus on the benefits, but also—Make sure they thoroughly explain the risks associated with the procedure and the downtime period.Please do so. Another important point is whether they show a willingness to answer questions sincerely.
■Is the location convenient enough to make it easy to keep coming here?
Healthy skin doesn’t happen overnight, and if you want to truly feel the effects of your treatments, regular visits to the clinic are key. Choosing a clinic that’s conveniently located near your home or workplace will make your visits less of a burden and lower the barrier to getting treatment.
What Exactly Is Rejuran? An Injection Treatment for Healthy Skin
In the following section, we’ll explain the characteristics of Rejuran’s basic ingredients and the differences between the various injection methods.
■Effects of "Polynucleotide (PN)," the Main Ingredient in Rejuran
Rejuran is a South Korean-developed drug whose main ingredient is a polynucleotide (PN) derived from salmon DNA. Polynucleotides are,It is expected to bring out the skin's natural health, and the injections are designed to improve skin quality.. This treatment is ideal for those looking to improve skin firmness and reduce wrinkles.
■ A Doctor’s Skill Matters! The Differences and Benefits of “Manual” vs. “Machine” Procedures
There are two methods for administering Rejuran: manual injection, in which a doctor administers the injection using a syringe, and automated injection, which uses a specialized device. The characteristics of each method are summarized in the table below. Manual injection of Rejuran is,Doctors can focus treatment on specific areas while monitoring the patient's skin condition.So, consider this option when you want to focus on caring for specific, small areas.
| Handmade | Machine-printed | |
| feature | Examine the condition of each area and treat specific areas, such as fine lines | Enables broad, fast, and uniform treatment |
| demerit | People who are more prone to pain compared to those who use a typewriter | It is difficult to perform precise treatments on specific areas, such as fine wrinkles around the eyes. |
| Suitable for. | For those who want to target and effectively treat fine lines, dark circles, acne scars, and other specific concerns | For those looking to improve the overall texture of their skin—such as by enhancing firmness and refining the skin's texture— |
■ Characteristics of Different Types of Rejuran and Their Recommended Application Sites
Rejuran offers several product lines tailored to specific areas of concern. The standard “Rejuran (Healer)” is used for basic care of the entire face; the low-viscosity “Rejuran i (Eye)” is used for the thin, delicate skin around the eyes and for fine lines; and the high-viscosity “Rejuran S” is used for treating pitted scars and hardened scars.
At Hiroshima Yayoi Clinic, we use Rejuran i (Rejuran Eye), which is suitable for injections into areas with thin skin, such as around the eyes. The expected results are as follows.
| part | Expected Benefits |
| Outer corners of the eyes and the area around the eyes | Care for Wrinkles and Fine Lines |
| Thinning skin around the eyes | Improved Firmness |
| Dark Circles and Dullness Under the Eyes | Refine skin texture, brighten skin tone |
■If you're considering a Rejuran manual treatment in Hiroshima, schedule a consultation to discuss your options.
For those in Hiroshima considering a manual Rijuran treatment, we’ve outlined the expected results and key points to consider when choosing a clinic. One of the main advantages of the manual technique is its ability to precisely target delicate areas such as the under-eye region and fine lines. Even if you’re concerned about pain, the procedure can be made more comfortable through measures such as topical anesthesia and cooling. Why not start by discussing your concerns during a consultation at a clinic?
Aesthetic Dermatology, Aesthetic Medicine, Aesthetic Surgery, Art Make-up Yayoi Clinic (YAYOI CLINIC) in Hiroshima introduces treatments for different problems of the skin, body, and face.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
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Description of treatment] Rejuran
Recommended frequency of treatment: 3 to 4 times every 2 to 3 weeks / once every 6 months as maintenance.
Cost】¥58,000〜¥204,000 ※Prices vary depending on the area and number of times.
Side effects/risks] Pain, redness, swelling, internal bleeding
Equipment used.
Rejuran treatments include procedures using unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
