Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
If you’re thinking, “I want to improve my skin, but I’m hesitant about treatments that involve needles,” or “I want to minimize downtime as much as possible,” then YAYOI CLINIC’s Target Cool is the perfect choice for you. In this article, we’ll introduce the features and three key benefits of Target Cool.
YAYOI CLINIC's Target Cool offers a choice of two formulations depending on your concerns.
YAYOI CLINIC’s Target Cool is a product from BIANCA CLINIC, a leading company in aesthetic medicine,Under the supervision of Dr. Yukitaro Ikeda, we carry only carefully selected products.。
You can choose from the following formulations based on your concerns and goals.
"Tranexamic Acid"
- Whitening effect
- Anti-inflammatory effects
"Botox"
- Pore tightening
Another feature of Target Cool is that you can choose the treatment based on your skin condition and concerns.
Advantage #1: [Medication can be administered while minimizing pain]

Target Cool rapidly cools the medication while spraying it at high speed, therebyDelivers beauty ingredients to the stratum corneum without using needlesThis is a treatment. Unlike treatments that involve injections, this procedure is designed to minimize discomfort and reduce the burden on your skin.
Unlike administration via injection, this method does not involve inserting a needle, soPain-Sensitive TreatmentThis treatment is perfect for those who think, “I want to improve my skin, but I’m not a fan of injections…”
Benefit #2: [Supports the Skin's Health When Combined with CO2]

Introducing CO₂ along with the drug provides the following benefits, including the Bohr effect:
- Inflammation Relief
- Inhibits oxidation
- Promotes blood circulation
It supports skin renewal through the action of CO2, andIts anti-inflammatory properties are expected to promote healthy, beautiful skinCan be done.
Attraction #3: [Can Be Combined with Other Treatments]

Target Cool is,It is also suitable for use in combination with cosmetic procedures that involve downtime.. Since it cools the skin after treatment while delivering the active ingredients to the stratum corneum, it can help restore the skin to a healthy condition.
It is particularly well-suited for use with microneedle treatments such as those described below and is incorporated into post-treatment skincare routines.
[Microneedle Treatment]
- Therma Needle
- Potenza
- dermapen
By cooling the treated area with Target Cool after these procedures,Expected to reduce downtime, such as redness and flushingYes, it is possible. In addition, some clinics in South Korea have adopted this method to reduce post-procedure inflammation and minimize downtime.
At YAYOI CLINIC, we recommend treatment combinations tailored to each individual’s specific needs and skin condition.
Target Cool Pricing

The cost of a Target Cool treatment—whether for Botox or tranexamic acid infusion—is typically 27,500 yen (tax included) per session.
For Target Cool, visit YAYOI CLINIC
Target Cool is a treatment recommended for those who are hesitant about needle-based procedures or who want to continue their skincare routine while minimizing downtime. At Yayoi Clinic, we select the appropriate solution based on your specific concerns and propose a treatment plan tailored to each individual. If you’re interested, please feel free to contact us for a consultation.
Aesthetic Dermatology, Cosmetic Medicine, Cosmetic Surgery, and Art Makeup in Hiroshima YAYOI CLINIC offers treatments for different problems of the skin, body, and face.
In order to offer a better option to our customers, we will assess the skin condition of each individual and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
Description of treatment] Targeted Cool
The treatment interval depends on the purpose of the treatment.
Cost】¥22,000〜¥63,000 ※Fees vary depending on the number of times, etc.
[Side effects/risks] Temporary redness and swelling, hypercooling, hyperpigmentation, itching, increased sensitivity, blistering, and changes in skin sensation.
Equipment used.
TargetCool® treatments include procedures using domestically unapproved drugs or medical devices.
Drugs and medical devices used for treatment were imported through a private importation procedure based on the judgment of a physician at our clinic.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
-FDA, CE, KFDA (MFDS) approval
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Thermoneedle
Approximate number of times of treatment] Once every 4 weeks (1 course: about 5 times recommended)
*The treatment interval depends on the degree of bleeding.
Cost] 1 time ¥44,000~¥55,000
Side effects/risks: Redness, petechial hemorrhage spots, roughness, peeling, hyperpigmentation, scabs, scars, etc.
Equipment used.
The treatment of thermoneedles involves the use of domestically unapproved drugs or medical devices.
Drugs and medical devices used for treatment were imported through a private importation procedure based on the judgment of a physician at our clinic.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Significant risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
[Description of treatment] Potenza
Approximate number of treatments: 3 times every 4 to 6 weeks (every 2 weeks for melasma)
*The number of treatments varies depending on the treatment.
[Cost] Per session: ¥49,800–¥299,000* (Varies depending on the number of sessions and treatment details.)
Approximate duration of treatment: 3 to 5 months
Adverse effects/risks
Infection, hyperpigmentation, folliculitis, erythema
After the procedure, the pores may become blocked due to inflammation or swelling, and temporary acne may develop or worsen.
Depending on the treatment, bleeding may occur.
Swelling and redness may occur after the procedure.
Please note that effects may vary from person to person. Also, depending on the area to be treated, some patients may not achieve outstanding results.
Equipment used.
Treatment of potenza includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Jeisys Medical Inc. under the judgment of our doctors. Please refer to the following for information on drugs and medical devices that should be imported by individuals.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
-MFDS(2019.01)
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Dermapen 4
Approximate number of treatments: Once every 2 to 4 weeks, or once every 6 to 8 weeks (1 course: 3 to 5 treatments)
*The treatment interval depends on the degree of bleeding.
Cost] 1 time ¥31,800~¥36,800
Adverse effects/risks
Redness and tingling may occur, but will generally subside within 1 to 2 days.
Symptoms such as peeling, internal bleeding, and swelling may appear for 7-10 days.
In rare cases, old keratin may peel off, but please be careful not to peel it off forcibly.
Equipment used.
Dermapen4 treatment involves the use of a domestically unapproved drug or medical device.
The drugs and medical equipment used for treatment were purchased from PRSS.Japan, Inc. under the judgment of our doctors.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
ISO 13485
CE Standard
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.