Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
Although both the dermis and subcutaneous tissue are located within the skin, they each play distinct roles. Understanding how the dermis—which is responsible for skin firmness and elasticity—functions will make it easier to choose the right cosmetic treatment for your specific skin concerns. In this article, we’ll explain the differences between the dermis and subcutaneous tissue, and provide a detailed overview of the characteristics and types of “skin-nourishing injections” that target the dermis directly.
Let's Learn About the Structure of the Skin
The structure of the skin is broadly divided into three layers: the “epidermis,” the “dermis,” and the “subcutaneous tissue,” with the epidermis being the outermost layer. The outermost layer of the epidermis is the stratum corneum, andThe thickness is approximately 0.01 to 0.03 mm, which is about the same as a single sheet of plastic wrap.. Since cosmetics generally only penetrate as far as the outermost layer of the skin (the stratum corneum), it is generally considered difficult to deliver active ingredients to the dermis through surface-level skincare.
Each layer has the following roles:
| 層 | Main Role |
| skin | The Skin's Protective Barrier Function |
| Dermis | Supports firmness, elasticity, and hydration |
| Subcutaneous tissue | Contains fat and serves to absorb shock and retain heat |
The dermis forms the foundation of the skin
The dermis contains collagen, hyaluronic acid, elastin, and other components that help maintain the skin’s firmness and hydration. Therefore,When collagen, hyaluronic acid, and elastin decrease, the skin's underlying structure weakens, leading to wrinkles and sagging.. This is why the dermis is often referred to as the foundation of the skin.
For targeting the dermis, we recommend skin-nourishing injections!
To improve skin conditions such as wrinkles and dryness,It is important to target the dermis, which forms the foundation of the skin.That's right. Since the skin-rejuvenating injection is administered into the dermis, it provides a direct approach. By replenishing the hyaluronic acid and collagen lost with age and strengthening the skin's foundation, it is expected to improve skin texture.
Types of Skin-Nourishing Injections Available at Yayoi Clinic
There are six types of skin-nourishing injections available at Yayoi Clinic. Let’s take a look at the types and ingredients.
〈ジュベルック〉
Main Ingredients: PDLLA (polylactic acid) and non-crosslinked hyaluronic acid
〈Rejuran〉
Main Ingredient: Polynucleotide extracted from salmon DNA
〈Hydro〉
Main Ingredients: Three types of hyaluronic acid with different molecular weights
〈Profilro〉
Main Ingredients: Two types of hyaluronic acid with different molecular weights
〈Bolite XC〉
Main Ingredient: Cross-linked Hyaluronic Acid
〈Sunecos〉
Main Ingredients: Non-crosslinked hyaluronic acid, 6 types of amino acids
If you want beautiful skin, you need to care for both the epidermis and the dermis
The dermis is often referred to as the foundation of the skin, butYou must not neglect the care of the outer layer that serves as the roof.. Use doctor-formulated skincare products to condition the epidermis and skin treatments to revitalize the dermis. Furthermore, skin-rejuvenating injections help rebuild the dermis, allowing you to achieve beautiful skin through this dual-pronged approach.
Get 30% OFF skin-nourishing injections when you sign up as a trial participant!
We are pleased to announce the launch of our Skin Rejuvenation Injection Select Plan! The Select Plan is designed for those who are unsure which treatment is right for them. During a consultation, a doctor will listen to your concerns and help you choose the most suitable treatment. As this is a special introductory offer, we’re offering a 30% discount off the regular price. Let’s work toward achieving clear, radiant skin that glows from within with Yayoi Clinic’s Skin Rejuvenation Plan.
For skin growth injections, go to YAYOI CLINIC
The dermis is a vital layer that supports the skin’s firmness and elasticity. Skin-rejuvenating injections are a treatment that targets the dermis directly to improve skin texture and enhance firmness and hydration.
At Yayoi Clinic, we offer six types of skin-nourishing injections and recommend the most suitable treatment based on your specific concerns and skin condition. If you’re unsure which treatment to choose, please feel free to consult with us.
Aesthetic Dermatology, Cosmetic Medicine, Cosmetic Surgery, Art Makeup in Hiroshima YAYOI CLINIC offers treatments for different skin, body, and facial concerns.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
[Description of treatment] Jubeluk
Approximate number of treatments
Fine wrinkles: 1-2 times per month
Skin texture improvement: about twice per month
Acne scars: about 3 times per month
*Depends on the condition of the skin.
Cost: ¥55,000-199,800 per session
Adverse effects/risks
Redness, swelling, and swelling at the injection site
Equipment used.
JUVELEC's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
U.S. Food and Drug Administration (FDA)
Ministry of Food and Drug Safety of Korea (MFDS)
CE Medicines in Europe
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Rejuran
Recommended frequency of treatment: 3 to 4 times every 2 to 3 weeks / once every 6 months as maintenance.
Cost】¥58,000〜¥204,000 ※Prices vary depending on the area and number of times.
Side effects/risks] Pain, redness, swelling, internal bleeding
Equipment used.
Rejuran treatments include procedures using unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Hydro
Approximate number of treatments: 3-4 times every 2 weeks
Cost] ¥71,000 - ¥204,000 *Prices vary depending on the area and number of times.
Adverse effects/risks
Tingling, itching, redness, and heat may occur for about 2 days after treatment.
Swelling may remain for 1-2 days and internal bleeding for about 7 days, but usually resolves spontaneously.
Depending on the individual and the injection site, the puffiness may remain for 1-3 days after treatment. It will settle naturally as the drug is diffused.
Equipment used.
Hydro treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Obtained European CE Mark[p1].
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
[Description of treatment] Profilo
Approximate number of treatments
Initial: 2 times at 1 month intervals
After the second time: once every six months
*The number of treatments depends on the skin age.
Cost] ¥82,000 - ¥158,400 *Prices vary depending on the number of times.
Side effects/risks] Pain at the injection site, inflammation, redness, itching, swelling, internal bleeding, allergic reaction due to body constitution, etc.
Equipment used.
Profibro's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
[Treatment Details] Volite (injection of a cross-linked hyaluronic acid preparation)
Duration and number of times of treatment] Every 1 time
[Price] ¥69,800 per bottle
Risks and side effects] Internal bleeding, redness, swelling, edema, itching, pain, allergies, etc.
[Regarding treatment using unapproved medical devices, unapproved pharmaceuticals, etc.
This treatment includes procedures using drugs or medical devices not approved in Japan.
Information on safety, etc. in other countries
—Juvederm Vista® Volite XC has received regulatory approval for the correction of superficial depressions, such as fine lines on the face and neck, and for improving skin condition (including hydration and elasticity).
—Medical Device Approval Number: 30200BZX00389000
There is a possibility that serious risks, side effects, etc. have not been identified.
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief Program.
Description of treatment] Snechos
Approximate number of treatments] Once every 2 weeks x 3-4 times (1 course) *Depends on the treatment.
Cost] ¥128,000 - ¥175,800 *Prices vary depending on the area and number of times.
Side effects/risks] bleeding, redness, swelling, tenderness, pain, itching, mild/moderate bruising, mild edema, internal bleeding, etc.
Equipment used.
Snekos treatment includes the use of unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
-The special ratio of amino acids in the drug has been patented internationally by an Italian development company.
-CE Mark Class III (European safety standard conformity approval)
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
