Dr. Yayoko Ito
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Graduated from Hiroshima University School of Medicine. After working in the Department of General Medicine, he studied under doctors at the forefront of cosmetic medicine. After acquiring knowledge and skills in aesthetics, he became the director of YAYOI CLINIC in 2023. Her specialties include Botox, hyaluronic acid injections, and customized sagging treatment. His motto is to provide natural and pain-free treatments with careful consultation.
Mesogun is a cosmetic medical treatment aimed at improving skin texture that is gaining attention in Hiroshima. In this article, Hiroshima Yayoi Clinic (YAYOICLINIC), a cosmetic dermatology clinic, explains the effects, mechanism, and pros and cons of Mesogun. We also answer frequently asked questions about the MesoGun. Use this article as a guide to determine if it’s right for your skin concerns and make the most of this treatment.
What Is a Mesogun? An Explanation of This Popular Beauty Treatment in Hiroshima

Mesogun is one of the beauty treatments gaining attention in Hiroshima. First, let’s take a look at some basic information about how it works, its effects, and how it differs from traditional beauty treatments.
■Hiroshima YAYOI CLINIC Explains How the Mesogun Works and Its Effects
The Mesogun is,A procedure in which a solution tailored to skin concerns such as fine lines and enlarged pores is injected directly into the dermis.. It is characterized by its ability to deliver the treatment solution quickly and evenly into the skin, and the key feature is that it minimizes the burden on the skin. It is considered relatively painless, and the procedure can generally be performed without anesthesia. In addition, the stimulation the needles provide to the skin promotes collagen production.Expected to address concerns such as sagging skin and enlarged poresThe following is a summary of the results of the project.
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■ Advantages and Disadvantages of the Mesogun
The benefits of the Mesogun are:The ability to fine-tune the depth of the needle as it penetrates the skin, and the compact design of the device's tipThat’s the point. These features make it possible to inject the solution into precise areas, such as under the eyes and the sides of the nose. Since the solution can be tailored to specific skin concerns and injected directly into the target areas, it can effectively address fine lines around the eyes and dark spots on the sides of the nose.
On the other hand, the disadvantages of the Mesogun are,Symptoms such as bruising or redness may occur after the procedureThat's it. Also,Depending on your physical condition or allergy history, you may not be able to receive treatment, so it is necessary to check in advance.It is.
■ Ingredients Used in the Meso Gun and Their Effects
You can choose the ingredients used in Mesogun treatments based on your specific skin concerns. Since the medications offered vary by clinic, it’s a good idea to check in advance. Below, we’ve listed some commonly used medications.
[Exo-Reem]
Recommended for caring for aging skin. It can help reduce skin inflammation and boost the skin’s regenerative abilities.
[Beautiful Skin Cocktail]
It helps suppress melanin production and brighten your skin tone. It also has anti-inflammatory properties that help reduce skin redness.
[Miracle H]
Miracle H is designed to stimulate collagen and promote its production. It smooths out uneven skin texture and can help improve firmness and radiance.
[NEW Shirayuki]
It helps address dullness and promotes a radiant, translucent complexion. It targets skin concerns such as dark spots and freckles, leaving your skin glowing and translucent.
Expected Benefits of the Meso Gun

Next, let's take a look at the benefits you can expect from the Meso Gun.
■Treating Dark Spots and Dullness
By using medications with skin-brightening effects, you can address dark spots and dullness. These medications help suppress melanin production and brighten your skin tone. They are also effective against post-acne hyperpigmentation and melasma. Some of these medications also have anti-inflammatory properties, which can help reduce skin redness.
■Treating Fine Lines and Sagging Skin
Skin rejuvenation treatments using a mesogun are also effective for addressing fine lines and wrinkles. The mesogun stimulates the skin with micro-needles, promoting the production of elastin and collagen. Additionally, by injecting substances such as hyaluronic acid and Rejuran to restore elasticity and firmness to the skin, these treatments aim to minimize the appearance of wrinkles and sagging.
■ Pore Tightening and Skin Firming
It also helps tighten pores and improve skin firmness. The Mesogun helps control excess sebum production and addresses pore-related concerns. By using solutions that promote skin renewal and target pores, you can achieve smooth skin with less noticeable pores.
Frequently Asked Questions About the MesoGun
Now, let's take a look at some frequently asked questions about the MesoGun.
■How much pain and downtime can I expect?
The key feature of the Mesogun is the speed at which it inserts needles into the skin.Since the needle remains in the skin for a shorter period of time, pain is reduced accordingly.... Additionally, when using the device on individuals who are sensitive to pain or on areas that are particularly sensitive to stimulation, you can fine-tune the depth to which the needle is inserted.
Furthermore, the Mesogun isRelatively short downtimeThat's the appeal.Results may vary from person to person, but in some cases, you may experience a stinging sensation or redness for a few days.
■When will I start to notice the effects?
The Mesogun isYou may notice a difference even after just one treatment.Although results vary from person to person, effects are typically noticeable about 3 to 5 days after the treatment, once the needle marks have subsided.
The effects of Mesogun treatment wear off after a certain period of time. If you wish to maintain more lasting results,Regular treatments every 2 to 3 monthsWe recommend that you take it.
■How is it different from Dermapen or hydrafacial injections?
Treatments similar to the Mesogun include the Dermapen and hydrafacial injections. I’ve summarized the differences between them below.
[Dermapen]
Both the Dermapen and the Mesogun are treatments that are effective for addressing enlarged pores and acne scars, as well as improving skin elasticity. The main difference between the Mesogun and the Dermapen is that,The number of needles used and the method of administering the medicationIt can be found here. The details of the differences are summarized in the table.
| Mesogun | dermapen | |
| Treatment Method | Inject the medication at the same time the needle is inserted | Apply the medication after pricking the skin with a needle |
| Number of needles | one (object) | 16 pcs. |
While the Dermapen creates tiny holes in the skin before applying the medication, the Mesogun can inject the medication at the same time as it penetrates the skin, allowing it to be delivered directly to the dermis. There is also a difference in the level of pain, andThe MesoGun causes less discomfort during treatment than the Dermapen.
[HydraFacial]
While the Mesogun and hydrafacial are similar in that they both involve injecting medication under the skin,There are differences in the depth of the approach and the number of needles used.The details of the differences are as follows.
| Mesogun | injection of water into the eye of a patient | |
| Treatment Method | Continuous, high-speed injection of medication | Inject the medication as if stamping it on |
| Number of needles | one (object) | Nine. |
| The demographic to be approached | Superficial to deep layers of the dermis | The superficial layer of the dermis |
The MesoGun targets skin depths ranging from 0.5 to 10 mm. In contrast, the HydraFacial injects the solution into the shallow dermis, at a depth of 0.2 to 0.4 mm. The MesoGun allows for fine-tuning of the needle insertion depth and is used not only for facial treatments but also for treating thinning hair.
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■ Conclusion.
Mesogun is a cosmetic treatment available in Hiroshima that involves minimal pain and downtime. By selecting the appropriate solution based on your specific skin concerns and undergoing the treatment, you can achieve a vibrant complexion. In addition to Mesogun, other treatments that involve inserting needles into the skin include hydrafacials and Dermapen, each with its own unique effects and characteristics. If you’re unsure which treatment is right for you, it’s a good idea to visit a clinic and consult with a specialist. Why not use this article as a guide to achieve beautiful, radiant skin?
Aesthetic Dermatology, Aesthetic Medicine, Aesthetic Surgery, Art Make-up Yayoi Clinic (YAYOI CLINIC) in Hiroshima introduces treatments for different problems of the skin, body, and face.
In order to offer a better option for everyone, we will assess each person's skin condition and formulate a treatment plan that meets their needs in terms of treatment duration, budget, and acceptable downtime.
If you have any concerns, please come for a counseling session first.
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Description of treatment] Mesogan
Approximate number of treatments: 1-3 treatments per course *The number of treatments depends on the purpose and skin condition, and therefore varies from person to person.
Cost】 ¥59,800~¥69,800
Side effects/risks] Swelling, redness, pain, internal bleeding, scarring, itching, allergic reaction to the drug or metal, hyperpigmentation, hypersensitivity, temporary folliculitis, etc.
Equipment used.
Mesogun treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
MP Gan is approved by the U.S. FDA.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
Description of treatment] Dermapen 4
Approximate number of treatments: Once every 2 to 4 weeks, or once every 6 to 8 weeks (1 course: 3 to 5 treatments)
*The treatment interval depends on the degree of bleeding.
Cost] 1 time ¥31,800~¥36,800
Adverse effects/risks
Redness and tingling may occur, but will generally subside within 1 to 2 days.
Symptoms such as peeling, internal bleeding, and swelling may appear for 7-10 days.
In rare cases, old keratin may peel off, but please be careful not to peel it off forcibly.
Equipment used.
Dermapen4 treatment involves the use of a domestically unapproved drug or medical device.
The drugs and medical equipment used for treatment were purchased from PRSS.Japan, Inc. under the judgment of our doctors.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
ISO 13485
CE Standard
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.